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L-2-Nitrophenylalanine (CAS 19883-75-1) is a Unprotected nitroaromatic amino-acid analog selected for SAR studies, reference chemistry and derivatization of an unusual aromatic residue. This positions it within noncanonical amino-acid and medicinal-chemistry research.
Because the amino and carboxyl groups are not preprotected for Fmoc-SPPS, select a protection strategy that matches the intended synthetic route. For reproducible work, confirm identity and protection state against the COA before transferring conditions from a related analog.
Product Information
| Product Name | L-2-Nitrophenylalanine |
| Catalog No. | AS4243 |
| CAS No. | 19883-75-1 |
| Molecular Formula | C9H10N2O4 |
| Molecular Weight | 210.19 g/mol |
| Compound Type | Unprotected nitroaromatic amino-acid analog |
| Primary Research Use | Noncanonical amino-acid and medicinal-chemistry research |
Noncanonical Residue Chemistry
L-2-Nitrophenylalanine introduces an unusual side chain into an amino-acid framework. It can support SAR work, reference chemistry and preparation of protected derivatives for peptide or medicinal-chemistry programs.
Protection Before Peptide Assembly
The amino and carboxyl functions are not supplied as a standard Fmoc/tBu SPPS building block. If the residue is intended for peptide synthesis, a protection strategy should be selected to match the coupling and deprotection sequence.
Identity and Stereochemistry
Procurement should confirm the stated stereochemistry together with CAS, formula and analytical specification. Noncanonical amino acids with similar aromatic substituents are not interchangeable.
Browse the unusual residue building blocks for related structures. Complex sequence work can also use specialty peptide building blocks.
Product Documents
MSDS - L-2-Nitrophenylalanine (AS4243)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Why does the exact derivative matter?
L-2-Nitrophenylalanine is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.
Can a close analog replace L-2-Nitrophenylalanine?
Not safely by name alone. For L-2-Nitrophenylalanine, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.
What should procurement verify?
Match the product to CAS 19883-75-1 and the lot-specific COA rather than relying only on a shorthand chemical name.