$485.71 - $1457.14
Fmoc-5-methoxy-L-Tryptophan (CAS 460751-69-3) is supplied as a Protected amino-acid / peptidomimetic building block. In research synthesis, it is most relevant to peptide, peptidomimetic and medicinal-chemistry synthesis and a methoxy-substituted indole side chain for modified tryptophan chemistry.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.
Product Information
| Product Name | Fmoc-5-methoxy-L-Tryptophan |
| Catalog No. | AS4273 |
| CAS No. | 460751-69-3 |
| Molecular Formula | C27H24N2O5 |
| Molecular Weight | 456.49 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Application in Peptide and Peptidomimetic Design
Fmoc-5-methoxy-L-Tryptophan expands accessible chemical space through a methoxy-substituted indole side chain for modified tryptophan chemistry. This makes the product most relevant to sequence-defined SAR, conformational studies or specialized synthetic targets.
What to Check Before Incorporation
Confirm stereochemistry, free versus protected functional groups and the planned cleavage sequence. These details affect activation choice, solubility and the identity of the final residue.
Procurement Relevance
Use CAS 460751-69-3 together with the full product name when comparing suppliers. Similar shorthand names can refer to different positional isomers or protection states.
Additional chemistry is available in the specialty amino acid set. For synthesis planning beyond the building block, see specialty SPPS building blocks.
Product Documents
MSDS - Fmoc-5-methoxy-L-Tryptophan (AS4273)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Frequently Asked Questions
What distinguishes Fmoc-5-methoxy-L-Tryptophan in synthesis?
Its intended role is peptide, peptidomimetic and medicinal-chemistry synthesis, with the exact residue or functional-group state defined by the product structure.
Why check the protection map for Fmoc-5-methoxy-L-Tryptophan?
In Fmoc-5-methoxy-L-Tryptophan, the protection state determines which functions remain reactive and which deprotection conditions can be used later in the route.