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Fmoc-NH2 (CAS 84418-43-9) is an Fmoc-derived carbamate used in protected nitrogen-source chemistry and synthetic-method development. Its main synthetic value is ammonia surrogate and C-N bond-forming chemistry.
Use it when the nitrogen-containing Fmoc unit is a reaction component, not merely when an amine needs Fmoc protection. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Fmoc-NH2 |
| Catalog No. | AS3013 |
| CAS No. | 84418-43-9 |
| Molecular Formula | C15H13NO2 |
| Molecular Weight | 239.27 g/mol |
| Compound Type | Fmoc-derived carbamate |
| Primary Research Use | Protected nitrogen-source chemistry and synthetic-method development |
Fmoc-NH2 as a Protected Nitrogen Source
9-Fluorenylmethyl carbamate has been used as a protected ammonia equivalent in synthetic transformations that generate N-Fmoc-protected products. This makes the material relevant when nitrogen is introduced as part of the reaction rather than when an existing amine simply needs protection.
How Fmoc-NH2 Differs from Fmoc Transfer Reagents
Fmoc-Cl and Fmoc-OSu are activated reagents that transfer an Fmoc group to an existing amine. Fmoc-NH2 is the carbamate itself. The distinction matters in procurement because the three materials share a fluorenylmethoxycarbonyl motif but perform different synthetic roles.
Selection and Experimental Considerations
Reaction compatibility depends on catalyst, reaction partner, solvent, temperature and downstream deprotection. Confirm CAS 84418-43-9 and the requested analytical specification when comparing Fmoc-NH2 with other fluorenylmethyl reagents.
Related options are grouped under small-molecule specialties.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is another name for Fmoc-NH2?
Fmoc-NH2 is commonly identified as 9-fluorenylmethyl carbamate and is also called Fmoc-amide.
Can Fmoc-NH2 act as an ammonia surrogate?
Yes. It has been used as a protected nitrogen source in selected C-N bond-forming reactions.
Is Fmoc-NH2 the same as Fmoc-Cl or Fmoc-OSu?
No. Those are activated Fmoc-transfer reagents; Fmoc-NH2 is the carbamate itself.