Kemptide Negative Control is a synthetic peptide designed to serve as a specificity control in protein kinase C (PKC) activity assays. Based on the native Kemptide sequence (RRLSSLSLK), this negative control typically contains mutations (e.g., serine-to-alanine substitutions) at the PKC phosphorylation sites, rendering it non-substrate for PKC-mediated phosphorylation. By lacking the functional phosphorylation targets, it helps researchers validate assay specificity, distinguish non-specific background signals, and confirm that observed phosphorylation events are indeed PKC-dependent. This control is essential in biochemical experiments, such as kinase activity measurements or inhibitor screening, to ensure accurate data interpretation and eliminate false positives, supporting reliable results in studies of PKC signaling pathways and drug discovery.

Chemical Formula: C32H61N13O8

Molecular Weight: 755.93

Sequence: Leu-Arg-Arg-Ala-Ala-Leu-Gly

Purity: From crude to 98%

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Research Use Only