H-Val-Ala-Gly-Gly-Phe-Gly-PAB is a peptide-PAB linker intermediate built around the Val-Ala-Gly-Gly-Phe-Gly motif and a para-aminobenzyl (PAB) spacer. It is intended for research on cleavable linker architecture, linker assembly and bioconjugation chemistry rather than as a free bioactive peptide.

The product is best understood as a modular synthetic intermediate: the peptide sequence provides an enzyme-responsive segment in relevant linker designs, while the PAB unit is commonly used as a self-immolative spacer in drug-linker chemistry. Lot-specific identity and purity should be confirmed before incorporation into a conjugation workflow.

Product Information

Role in Cleavable Linker Research

The Val-Ala-Gly-Gly-Phe-Gly-PAB architecture is relevant to peptide-cleavable linker development. In established ADC designs, GGFG-containing sequences can be combined with PAB-type self-immolative spacers so that enzymatic cleavage and spacer fragmentation are separated functions. For AS4086, the extended Val-Ala-GGFG sequence should be treated as a research linker precursor unless cleavage behavior is validated in the intended system.

Distinguishing the PAB Precursor from Activated Linkers

This material is not the same as MC-GGFG-PAB-PNP, PAB-PNP, or a payload-conjugated linker. Those products contain additional reactive or activated groups. Match the exact structure to the planned linker-assembly step before ordering.

Procurement and QC Considerations

Confirm the exact peptide sequence, PAB termination, molecular mass and HPLC/MS identity. PAB-containing linker intermediates can be confused with activated PNP carbonates or maleimide-containing derivatives, which are different products and should not share a CAS or specification.

Related materials can be reviewed under impurity and research standards.

For broader sequence or project work, see peptide linker synthesis.

Linker Identity and Reactive-State Control

Peptide-PAB intermediates should be ordered against the exact sequence and terminal chemical state. PAB-OH, activated PAB derivatives and payload-bearing linkers are different materials and can show similar naming across supplier catalogs.

For linker assembly, lot-specific HPLC and mass data are useful for confirming the intended intermediate before conjugation. If a prepared solution will be stored or reused, solution stability should be established under the selected solvent and concentration conditions.

Product Documents

MSDS - H-Val-Ala-Gly-Gly-Phe-Gly-PAB (AS4086)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-Val-Ala-Gly-Gly-Phe-Gly-PAB?

It is Val-Ala-Gly-Gly-Phe-Gly-PAB, a defined research compound with sequence or structural identity Val-Ala-Gly-Gly-Phe-Gly-PAB.

Is this a complete antibody-drug conjugate linker?

No. It is a peptide-PAB linker intermediate and does not by itself include every conjugation handle, activation group or payload component used in a complete ADC linker.

Why is the exact PAB termination important?

PAB-OH, PAB-PNP and other activated PAB derivatives are chemically different intermediates with different downstream reactivity.

Research Use Only.