H-D-Leu-Leu-OH; CAS 38689-31-5 is D-leucyl-L-leucine, a stereochemically defined short peptide with sequence D-Leu-Leu. Its D/L configuration is a primary part of the chemical identity rather than a naming detail.

The material is useful when researchers need a defined stereochemical comparator for peptidase recognition, chromatographic behavior or other sequence-specific biochemical studies. It should not be substituted with an L/L or other stereoisomer solely because the molecular formula is the same.

Product Information

Stereochemical Reference Value

D/L configuration can strongly affect peptidase recognition, transport and proteolytic stability while leaving nominal molecular formula unchanged. This product is therefore most useful when paired with a defined stereoisomeric comparator and consistent analytical conditions.

Why Stereochemical Identity Matters

Short peptides can show large stereochemistry-dependent differences in enzyme recognition and chromatographic behavior. Formula and nominal mass cannot distinguish all stereoisomers, so configuration and salt/ester state should remain explicit in records and sample labels.

Procurement and QC Considerations

For stereochemistry-dependent work, purchase against the exact D/L sequence and request lot-specific analytical documentation. MS alone confirms mass but does not establish absolute configuration.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Lot Documentation and Stereochemical Identity

For experiments in which configuration affects enzyme recognition, chromatography or biological stability, the D/L designation should be verified from lot-specific documentation rather than inferred from molecular mass alone. HPLC and MS can support purity and mass identity, but they do not by themselves establish absolute stereochemistry.

If the material will be used quantitatively, review the lot-specific purity basis and preparation concentration. Nominal vial mass should not be interpreted as independently determined net peptide content unless that value is provided in the accompanying analytical documentation.

Product Documents

MSDS - H-D-Leu-Leu-OH (AS4161)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-D-Leu-Leu-OH?

It is D-leucyl-L-leucine, a defined research compound with sequence or structural identity D-Leu-Leu.

Can another stereoisomer be substituted?

Not when stereochemistry is part of the experiment. Different D/L configurations can share molecular mass but differ in enzyme recognition, packing and chromatography.

Can MS alone confirm stereochemistry?

No. Mass spectrometry can support molecular-mass identity but does not establish absolute configuration by itself.

Research Use Only.