$213.00 - $1087.00
H-Glu(OEt)-OEt·HCl is L-glutamic acid diethyl ester hydrochloride. Both the α-carboxyl and side-chain γ-carboxyl groups are esterified with ethyl groups, while the amino function is supplied as the hydrochloride salt.
Blocking both carboxyl groups allows chemistry to be directed toward the amino terminus or other transformations without immediate carboxylate reactivity. The material is widely useful as a solution-phase intermediate rather than a direct standard residue for iterative peptide elongation.
Product Information
| Product Name | H-Glu(OEt)-OEt·HCl |
| Chemical Name | L-Glutamic acid diethyl ester hydrochloride |
| Catalog No. | AS2016 |
| CAS No. | 1118-89-4 |
| Molecular Formula | C9H18ClNO4 |
| Molecular Weight | 239.70 g/mol |
| Compound Type | L-glutamate diethyl ester hydrochloride |
| Primary Research Use | Protected dicarboxylate amino-acid intermediate for solution-phase synthesis |
Both Carboxyl Groups Are Ester-Protected
The two OEt groups suppress the acidic/reactive behavior of glutamate’s α- and side-chain carboxyl functions. Selective or global hydrolysis can later regenerate one or both carboxyl groups depending on the route and protecting-group strategy.
Because the two esters are chemically similar, true orthogonal deprotection is not inherent; selective chemistry must be validated rather than assumed.
Free Amino Group as an HCl Salt
The amino group is protonated in the isolated hydrochloride. N-acylation or N-protection normally requires suitable base handling and reaction design.
If a synthesis requires a chain-ready glutamate residue with orthogonal protections, compare protected glutamate building blocks.
Applications and Procurement
Diethyl L-glutamate HCl is useful in solution-phase peptide chemistry, heterocycle or small-molecule synthesis, and as a precursor to more specialized glutamate derivatives. CAS 1118-89-4 helps separate the L material from related salts and esterification states.
Product Documents
MSDS - H-Glu(OEt)-OEt·HCl (AS2016)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
How many carboxyl groups are esterified?
Both the α-carboxyl and side-chain γ-carboxyl groups are present as ethyl esters.
Is the amino group Fmoc-protected?
No. The amino group is supplied as the hydrochloride salt.
Can this be used directly for standard SPPS?
It is primarily a solution-phase/protected intermediate; standard SPPS usually uses a selectively protected, N-Fmoc glutamate building block.