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H-Glu(OtBu)-Gly-OH is an N-unprotected alpha-L-glutamyl-glycine dipeptide in which the glutamate side-chain carboxyl group is protected as a tert-butyl ester. The free amino terminus supports further extension while the side-chain acid remains masked.
We recommend checking linkage, stereochemistry and protecting-group position before treating any abbreviated Glu-Gly product name as interchangeable. For process intermediates, an accurate drawn structure is often more useful than the short name. LC-MS and NMR should be interpreted against that structure.
Product Information
| Product Name | H-Glu(OtBu)-Gly-OH |
| Catalog No. | AS4077 |
| CAS No. | 23406-82-8 |
| Molecular Formula | C11H20N2O5 |
| Molecular Weight | 260.29 g/mol |
| Chemical Identity | H-L-Glu(OtBu)-Gly-OH; alpha-L-glutamyl-glycine with side-chain tert-butyl ester |
| Primary Applications | Peptide-fragment extension, protected Glu-Gly motif synthesis and process-intermediate research |
Why the alpha-Glu-Gly assignment matters
CAS 23406-82-8 corresponds to the alpha-linked L-Glu-Gly structure. It should not be described as gamma-Glu-Gly. This distinction affects sequence mapping, downstream deprotection and impurity assignment, particularly in process-development work where closely related protected glutamyl fragments may coexist.
Synthetic role of the protection pattern
The N-terminus is available for acylation or peptide extension. The glutamate side-chain carboxyl is temporarily protected as OtBu and can be revealed under acid-labile deprotection conditions compatible with the overall route. The Gly carboxyl remains the C-terminus of the dipeptide.
Procurement and QC Considerations
Confirm CAS 23406-82-8, the stated molecular formula and lot-specific analytical identity. Review the COA together with the MSDS when the material will be used in sequence-sensitive or process-development work.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is H-Glu(OtBu)-Gly-OH an alpha- or gamma-glutamyl dipeptide?
CAS 23406-82-8 corresponds to alpha-L-Glu-Gly with the glutamate side-chain carboxyl protected as OtBu.
Why is the N-terminus free?
The free amino group allows further peptide extension or acylation.
Is this fully deprotected Glu-Gly?
No. The glutamate side-chain carboxyl remains protected as a tert-butyl ester.
Related Technical Resources
Browse related specialty peptide building blocks for protected amino acids, fragments and noncanonical synthesis intermediates.
For complete sequence work using this chemistry, see our custom peptide fragment assembly.