Boc-His(Trt)-Gly-OH is a protected His-Gly dipeptide fragment with Boc on the N-terminal histidine amino group, Trt on the histidine imidazole and a free C-terminal Gly carboxyl group.

The fragment is useful when the His-Gly motif is already fixed and a Boc-compatible, preassembled sequence unit simplifies downstream route design.

Product Information

Application Scope in Histidine-Containing Fragments

His-Gly motifs are used in peptide libraries, ligand design and fragment-based route development. A protected dipeptide can reduce one coupling step and isolate histidine stereochemical control upstream.

Imidazole Protection and Coupling

Trt masks the imidazole during protected chemistry, reducing side-chain participation. Histidine can still be sensitive to epimerization during activation, so fragment coupling should avoid unnecessarily aggressive base or prolonged preactivation.

Procurement and QC

Confirm CAS 1428125-85-2, C32H34N4O5, MW 554.65 g/mol, His-Gly order, L-His stereochemistry, N-Boc and imidazole-Trt protection.

For histidine-rich or fragment-based targets, route conditions can be reviewed through custom peptide synthesis.

Product Documents

A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.

Boc-His(Trt)-Gly-OH MSDS

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Which group is Trt-protected?

The histidine imidazole.

Is the terminal Gly carboxyl free?

Yes.

Why use a preformed His-Gly fragment?

It fixes sequence order and can reduce one downstream coupling step.

Related Technical Resources

Review practical peptide assembly

Research Use Only.