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Gastrin-1, human, commonly known as Gastrin I, Gastrin-17 or Little Gastrin, is a 17-amino-acid peptide used in studies of gastric endocrine signaling and cholecystokinin-2 receptor (CCK2R/CCKBR) pharmacology.
Its molecular form combines an N-terminal pyroglutamate, a glutamate-rich central region and the conserved amidated C-terminal gastrin sequence involved in receptor recognition.
Product Information
| Property | Specification |
|---|---|
| Product Name | Gastrin-1, Human |
| CAS No. | 10047-33-3 |
| Sequence | pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ |
| Peptide Length | 17 amino acids |
| Molecular Weight | Approximately 2098.2 Da |
| N-Terminus | Pyroglutamate |
| C-Terminus | Amide |
| Primary Target | CCK2R / CCKBR |
| Purity | Crude to 98% |
| Research Areas | Gastrin signaling, receptor pharmacology, gastric endocrine biology |
Sequence and Molecular Form
The mature sequence contains the conserved C-terminal:
Trp-Met-Asp-Phe-NH₂
This region is closely associated with CCK2R recognition. C-terminal amidation should therefore be treated as part of the intended molecular identity when comparing synthetic preparations.
The central glutamate-rich region gives Gastrin-17 a strongly acidic character and can influence reconstitution behavior and chromatographic retention.
We recommend confirming terminal chemistry, molecular mass and purity when Gastrin-17 is used in quantitative receptor or cell-based assays.
CCK2R Research Context
Human Gastrin-17 can support studies of CCK2R activation, gastric endocrine signaling, ligand–GPCR interactions and gastrin structure–activity relationships.
Structural studies of CCK2R provide a molecular basis for understanding how Gastrin-17 engages the receptor and support the importance of the C-terminal pharmacophore when designing receptor-focused experiments.
Researchers working with related ligands can explore the Gastrin, GRP & Bombesin Peptides collection.
Synthetic and Quality Considerations
Sequence identity alone does not fully define Gastrin-17. N-terminal pyroglutamate, C-terminal amidation and the expected molecular mass should be considered together with chromatographic purity.
Our Peptide Quality Control capabilities support analytical HPLC and mass spectrometry according to the selected product specification.
Frequently Asked Questions
Is Gastrin-17 the same as Big Gastrin?
No. Gastrin-17 and Gastrin-34 differ substantially in peptide length while retaining a related receptor-active C-terminal region.
Can modified Gastrin-17 analogs be prepared?
Sequence variants, labels and terminal modifications can be evaluated through our Chemical Peptide Synthesis capabilities.