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| Product Name | Fmoc-Val-OH |
|---|---|
| Synonyms | Nα-Fmoc-L-valine; Fmoc-L-valine |
| Catalog No. | AS0825 |
| CAS Number | 68858-20-8 |
| Molecular Formula | C20H21NO4 |
| Molecular Weight | 339.39 g/mol |
| Appearance | White powder |
| Melting Point | 140–155°C |
| Specific Rotation | -16.5° ± 2° (C=1 in DMF) |
| Storage Temperature | Cool, dry place (≤25°C) |
| Side-Chain Protection | None required |
| Primary Application | Fmoc-SPPS |
Product Overview
Fmoc-Val-OH (CAS 68858-20-8; catalog AS0825) is N-Fmoc-L-valine, a beta-branched amino acid building block for peptide synthesis. Its alpha-amino group is Fmoc-protected and its carboxyl group remains available for coupling. Valine has an isopropyl side chain with no additional functionality requiring side-chain protection in conventional Fmoc-SPPS.
Quality Specifications and Ordering
Purity: Alan Scientific supplies Fmoc-Val-OH at >99% purity.
Catalog pack sizes: 25 g, 100 g, 500 g, and 1 kg.
Quality documentation: See Product Documents below for lot-specific COA request details. Review the analytical methods and results reported for the supplied batch.
Quotation: Email [email protected] with AS0825, the pack size, total quantity, delivery destination, and required date. Confirm availability and dispatch lead time before ordering.
For difficult sequences, keep incoming-reagent specifications separate from target-peptide yield and purity. Describe any additional raw-material acceptance criteria in the inquiry.
Hindered Coupling and Sequence Context
The beta-branched side chain places steric bulk close to the peptide backbone. Incorporation near other hindered residues can require careful assessment of reaction completion, but a universal repeated-coupling rule is not appropriate for every Val-containing sequence.
Poor conversion can reflect more than the intrinsic reactivity of the incoming building block. Resin-bound aggregation and limited access to the growing chain may also contribute. Distinguish these possibilities before increasing activation severity or repeating unchanged conditions.
For the trade-off between resin capacity and accessibility in difficult sequences, review resin loading and aggregation in the SPPS practical guide before changing the synthesis strategy.
Applications in Hydrophobic Peptide Motifs
Fmoc-Val-OH is used in Val-containing research peptides, sequence libraries, and analogue panels investigating side-chain size and branching. Comparisons with Ala, Leu, or Ile alter different combinations of steric bulk and side-chain geometry; they are not interchangeable ways to add hydrophobicity.
For difficult sequences, evaluate resin loading, support solvation, and the overall residue pattern alongside coupling conditions. A lower loading may improve accessibility in some projects, but can reduce resin capacity and is not universally optimal. The final choice should follow the requirements and evidence from the actual synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis are batch-specific. Please contact us to request a COA, and we will provide it by email.
Frequently Asked Questions
Will purchasing >99% Fmoc-Val-OH eliminate incomplete coupling?
No. This product is supplied at >99% purity, but reagent purity does not remove steric hindrance, aggregation, or poor resin accessibility. Review the cause of low conversion before deciding whether to change the raw material, support, or coupling conditions.
Does valine need a side-chain protecting group?
No additional side-chain protection is needed for its isopropyl group in a conventional Fmoc-SPPS route.
Will stronger activation solve every difficult Val coupling?
No. Limited resin-bound accessibility or aggregation can also restrict conversion; the response should address the actual cause.
Research Use Only
For research use only. Not for human or veterinary use.