10.0% Off
$17.10 - $270.00
| Product Name | Fmoc-Tyr(tBu)-OH |
|---|---|
| Synonyms | Fmoc-O-tert-butyl-L-tyrosine |
| Product ID | 557 |
| Catalog No. | AS0709 |
| CAS Number | 71989-38-3 |
| Molecular Formula | C28H29NO5 |
| Molecular Weight | 459.53 g/mol |
| Appearance | White to off-white powder |
| Reference Melting Point | Approximately 150–156°C |
| Side-Chain Protection | tert-Butyl-protected phenolic hydroxyl |
| Primary Application | Fmoc-SPPS |
Product Overview
Fmoc-Tyr(tBu)-OH (CAS 71989-38-3; catalog AS0709) is an Fmoc-protected L-tyrosine building block with its phenolic hydroxyl protected as a tert-butyl ether. The alpha-carboxyl group remains free for peptide coupling. It is used to introduce tyrosine into conventional Fmoc/tBu solid-phase peptide synthesis while keeping the phenol protected during chain assembly.
Quality Specifications and Ordering
Purity: Alan Scientific supplies Fmoc-Tyr(tBu)-OH at >99% purity.
Catalog pack sizes: 25 g, 100 g, 500 g, and 1 kg.
Quality documentation: See Product Documents below for lot-specific COA request details. Review the analytical methods and results reported for the supplied batch.
Quotation: Email [email protected] with AS0709, the pack size, total quantity, delivery destination, and required date. Confirm availability and dispatch lead time before ordering.
Confirm that the route calls for phenolic O-tBu protection. Use the intended protection scheme, not a packaging or price comparison alone, to select the tyrosine derivative.
Phenolic Protection and Route Selection
The tBu ether masks the tyrosine hydroxyl during the protected synthesis stage. Fmoc is removed during routine basic elongation cycles, and an appropriate final acidic deprotection restores the phenolic hydroxyl.
This derivative is useful when reaction at the phenolic oxygen is not intended during assembly. If a route requires that oxygen to remain accessible, the unprotected-phenol derivative may be considered instead. The choice concerns functional-group availability and should not be presented as a difference between higher- and lower-quality tyrosine.
For a route requiring access to the phenolic hydroxyl before global deprotection, compare Fmoc-Tyr-OH and review compatibility with all planned reaction steps.
Tyrosine-Containing Peptides and Modification Planning
Applications include Tyr-containing research peptides, aromatic substitution panels, and defined synthetic intermediates. The phenolic group in the final deprotected peptide can contribute hydrogen bonding and other sequence-dependent interactions. Its biological role must be established in the complete peptide.
Fmoc-Tyr(tBu)-OH is neither a phosphotyrosine nor a sulfotyrosine building block. Such modifications require a separate installation strategy and compatible protection. A generic tyrosine product name is not enough to specify a modified residue for a synthesis order.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Frequently Asked Questions
Can Fmoc-Tyr(tBu)-OH be included in a multi-amino-acid SPPS order?
Yes. List AS0709 and the required quantity alongside the other building blocks. Its catalog pack sizes are 25 g, 100 g, 500 g, and 1 kg. Confirm that the route calls for the protected phenol; Fmoc-Tyr-OH is a different procurement choice.
How is this different from Fmoc-Tyr-OH?
Fmoc-Tyr(tBu)-OH has a protected phenolic oxygen; Fmoc-Tyr-OH has a free phenolic hydroxyl. They expose different functional groups during synthesis.
Is the tBu group normally retained in a fully deprotected Tyr peptide?
No. It is removed under the specified final deprotection conditions when native tyrosine is the target.
Research Use Only
For research use only. Not for human or veterinary use.