10.0% Off
$13.50 - $216.00
| Product Name | Fmoc-Gln(Trt)-OH |
|---|---|
| Synonyms | Nα-Fmoc-Nδ-trityl-L-glutamine; Fmoc-L-Gln(Trt)-OH |
| Catalog No. | AS8963 |
| CAS Number | 132327-80-1 |
| Molecular Formula | C39H34N2O5 |
| Molecular Weight | 610.70 g/mol |
| Primary Application | Fmoc solid-phase peptide synthesis (SPPS) |
Product Overview
Fmoc-Gln(Trt)-OH (CAS 132327-80-1) is an Fmoc-protected L-glutamine building block in which the side-chain amide nitrogen is protected with a trityl (Trt) group. It is used in Fmoc solid-phase peptide synthesis when a protected glutamine residue is required. Alan Scientific lists this material as catalog number AS8963, with molecular formula C39H34N2O5 and molecular weight 610.70 g/mol.
Quality Specifications and Ordering
Purity: Alan Scientific supplies Fmoc-Gln(Trt)-OH at >99% purity.
Catalog pack sizes: 25 g, 100 g, 500 g, and 1 kg.
Quality documentation: See Product Documents below for lot-specific COA request details. Review the analytical methods and results reported for the supplied batch.
Quotation: Email [email protected] with AS8963, the pack size, total quantity, delivery destination, and required date. Confirm availability and dispatch lead time before ordering.
Match L-glutamine and Trt side-chain protection to the sequence. Review the reported purity method and any required stereochemical testing as separate aspects of qualification.
Glutamine Protection in Peptide Synthesis
The alpha-amino Fmoc group is removed during iterative chain elongation, while the side-chain Trt group is retained under routine basic Fmoc-deprotection conditions. An appropriate acidic deprotection removes Trt to restore the glutamine side-chain amide in the finished peptide.
For long or compositionally challenging sequences, protected glutamine is only one part of the route. Coupling completeness, resin-bound aggregation, cleavage, and purification still need to be evaluated for the whole peptide. Neither side-chain protection nor high starting-material purity guarantees a specified crude-peptide purity.
Gln, Glu, and Asn Are Different Building Blocks
Glutamine has a side-chain carboxamide, whereas glutamic acid has a side-chain carboxylic acid. Fmoc-Gln(Trt)-OH and Fmoc-Glu(OtBu)-OH therefore introduce different residues and use different types of side-chain protection. They should not be substituted based on similar names.
Asparagine also contains an amide side chain, but with one fewer methylene group than glutamine. Selecting Gln rather than Asn changes the spacing and reach of that functionality. Applications include Gln-containing research sequences, peptide libraries, and analogue comparisons of side-chain hydrogen-bonding geometry; biological consequences require experimental validation.
For the shorter amide-containing side chain, compare Fmoc-Asn(Trt)-OH while keeping the target sequence and residue identity explicit.
Fmoc-Gln(Trt)-OH Is Not Fmoc-Gln-OH
Fmoc-Gln(Trt)-OH and Fmoc-Gln-OH are different chemical entities. The (Trt) designation means that the glutamine side-chain amide nitrogen carries a trityl protecting group. This changes the molecular formula, molecular weight and protection scheme.
When selecting material for peptide synthesis, verify the complete product name and CAS number rather than relying only on the abbreviated Fmoc-Gln portion of the name.
| Selection Point | Fmoc-Gln(Trt)-OH | Fmoc-Gln-OH |
|---|---|---|
| Side-chain designation | Trt-protected | No Trt group in the product name |
| Identity check | CAS 132327-80-1 | Verify the separate product identity and CAS number |
| Procurement rule | Match the intended protection scheme | Do not substitute based only on the amino-acid name |
Related Protected Amino Acid Building Blocks
Fmoc-Gln(Trt)-OH should also be distinguished from Fmoc-Glu(OtBu)-OH, which is a protected glutamic-acid derivative, and Fmoc-Asn(Trt)-OH, which has a shorter side-chain amide. These products are not interchangeable.
Product Documents
A MSDS is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. To request a COA, email [email protected] with the product name and catalog number. If you already have the material, include the lot number shown on the label. The SDS provides safety and handling information and does not replace the lot-specific COA.
Frequently Asked Questions
What is Fmoc-Gln(Trt)-OH?
Fmoc-Gln(Trt)-OH is an Nα-Fmoc, Nδ-Trt-protected L-glutamine derivative used as a building block in Fmoc solid-phase peptide synthesis.
What is the CAS number of Fmoc-Gln(Trt)-OH?
The CAS number of Fmoc-Gln(Trt)-OH is 132327-80-1.
Why does the product name include Trt?
Trt identifies the trityl group on the glutamine side-chain amide nitrogen and distinguishes this product from glutamine derivatives with a different protection state.
What should be checked before ordering?
Confirm the complete protected-amino-acid name, CAS number, required pack size and the current product specification or certificate of analysis for the lot being considered.
Research Use Only
For research use only. Not for human or veterinary use.