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| Product Name | Fmoc-Phe-OH |
|---|---|
| Synonyms | Nα-Fmoc-L-phenylalanine; Fmoc-L-phenylalanine |
| Catalog No. | AS0305 |
| CAS Number | 35661-40-6 |
| Molecular Formula | C24H21NO4 |
| Molecular Weight | 387.43 g/mol |
| Appearance | White powder |
| Melting Point | 180–195°C |
| Specific Rotation | -38° ± 2.5° (C=1 in DMF) |
| Storage Temperature | Cool, dry place (≤25°C) |
| Side-Chain Protection | None required |
| Primary Application | Fmoc-SPPS |
Product Overview
Fmoc-Phe-OH (CAS 35661-40-6; catalog AS0305) is N-Fmoc-L-phenylalanine, an aromatic amino acid building block for Fmoc peptide synthesis. Its alpha-amino group is protected by Fmoc, while its carboxyl group is free for coupling. Phenylalanine contains a benzyl side chain without a hydroxyl group and requires no side-chain protection in conventional Fmoc-SPPS.
Quality Specifications and Ordering
Purity: Alan Scientific supplies Fmoc-Phe-OH at >99% purity.
Catalog pack sizes: 25 g, 100 g, 500 g, and 1 kg.
Quality documentation: See Product Documents below for lot-specific COA request details. Review the analytical methods and results reported for the supplied batch.
Quotation: Email [email protected] with AS0305, the pack size, total quantity, delivery destination, and required date. Confirm availability and dispatch lead time before ordering.
Confirm that L-phenylalanine is intended. D/L comparison studies require separately identified building blocks; the >99% purity specification is not a substitute for stereochemical identification.
Aromatic Side-Chain Comparisons
Phe-containing analogues are used to investigate aromatic side-chain packing and the contribution of a phenyl group to peptide recognition. Comparing Phe with Tyr changes the presence of the phenolic hydroxyl as well as the chemical interactions available at that position.
An aromatic substitution can affect conformation, solubility, and target recognition simultaneously. Its consequences should therefore be established experimentally in the finished sequence rather than attributed to hydrophobicity alone.
For the aromatic analogue with a free phenolic hydroxyl, compare Fmoc-Tyr-OH and assess whether side-chain protection is needed for the planned route.
Peptide Assembly versus Fmoc-Dependent Material Behavior
Applications include aromatic research peptide motifs, sequence libraries, and synthetic peptide intermediates. In long or hydrophobic sequences, resin-bound accessibility and aggregation can influence coupling performance even when the starting amino acid meets its specification.
The Fmoc group is a temporary protecting group in a conventional peptide route. Properties of a molecule that retains Fmoc should not be assumed to describe a fully deprotected Phe-containing peptide. For materials research intentionally retaining an Fmoc group, define that structure separately from a standard peptide synthesis order.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis are batch-specific. Please contact us to request a COA, and we will provide it by email.
Frequently Asked Questions
How should I specify Fmoc-Phe-OH for a D/L comparison study?
This page covers the L-phenylalanine derivative, AS0305, CAS 35661-40-6. Identify the D derivative separately in the procurement list and state the required stereochemical test scope for each material. Do not use an overall purity value to infer that the two stereoisomers are interchangeable.
Does Fmoc-Phe-OH need side-chain protection?
Not for its benzyl side chain in conventional Fmoc-SPPS; the molecule has no side-chain hydroxyl, amine, or thiol to protect.
Is phenylalanine interchangeable with tyrosine?
No. Tyrosine carries a phenolic hydroxyl that changes chemical functionality and can require a different protection strategy.
Research Use Only
For research use only. Not for human or veterinary use.