$57.14 - $171.43
Fmoc-trans-D-4-Fluoro-Pro-OH (CAS 203866-20-0) is a Halogenated protected amino-acid building block used in fluorinated residue incorporation in peptide and medicinal-chemistry synthesis. Its main synthetic value is conformational, electronic and hydrophobicity tuning in peptide/SAR studies.
Select for a defined stereochemical and fluorination pattern; the effect of fluorination is position- and sequence-dependent. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Fmoc-trans-D-4-Fluoro-Pro-OH |
| Catalog No. | AS4246 |
| CAS No. | 203866-20-0 |
| Molecular Formula | C20H18FNO4 |
| Molecular Weight | 355.36 g/mol |
| Compound Type | Halogenated protected amino-acid building block |
| Primary Research Use | Fluorinated residue incorporation in peptide and medicinal-chemistry synthesis |
Role of the Halogenated Residue
Fmoc-trans-D-4-Fluoro-Pro-OH introduces a fluorinated amino-acid motif into peptide or small-molecule synthesis. Halogen substitution can alter local electronics, hydrophobicity and conformational preferences while preserving the core amino-acid connectivity.
SAR and Derivatization
The value of a halogenated residue is position-specific. In aromatic iodides, the iodine can also serve as a synthetic handle for selected cross-coupling or derivatization routes; fluorinated residues are more often retained as final structural features.
Selection Considerations
Verify substitution position and stereochemistry before ordering. Positional isomers with the same elemental composition can have materially different synthetic and biological behavior.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-trans-D-4-Fluoro-Pro-OH (AS4246)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Why does the exact derivative matter?
Fmoc-trans-D-4-Fluoro-Pro-OH is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.
Can a close analog replace Fmoc-trans-D-4-Fluoro-Pro-OH?
Not safely by name alone. For Fmoc-trans-D-4-Fluoro-Pro-OH, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.
What should procurement verify?
Match the product to CAS 203866-20-0 and the lot-specific COA rather than relying only on a shorthand chemical name.