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DBCO-acid (CAS 1353016-70-2) belongs to the dibenzocyclooctyne carboxylic acid class. It is used in copper-free click conjugation (SPAAC), particularly where DBCO derivatization, bioconjugation and azide capture is required.
Use when a carboxyl-functional DBCO handle is required for downstream activation or attachment before SPAAC. For reproducible work, confirm identity and protection state against the COA before transferring conditions from a related analog.
Product Information
| Product Name | DBCO-acid |
| Catalog No. | AS4213 |
| CAS No. | 1353016-70-2 |
| Molecular Formula | C19H15NO3 |
| Molecular Weight | 305.33 g/mol |
| Compound Type | Dibenzocyclooctyne carboxylic acid |
| Primary Research Use | Copper-free click conjugation (SPAAC) |
Role in Copper-Free Click Chemistry
DBCO-acid contains a strained dibenzocyclooctyne unit used for strain-promoted azide-alkyne cycloaddition (SPAAC). The carboxylic acid provides a separate attachment point for installing the DBCO group onto an amine-containing molecule before azide capture.
Conjugation Workflow
A typical route first converts the carboxyl group into a suitable amide-forming intermediate or activated derivative, then couples DBCO to the target amine. The resulting DBCO-functional molecule can subsequently react with an azide without a copper catalyst.
Selection Considerations
Distinguish DBCO-acid from preactivated DBCO-NHS esters and from DBCO derivatives carrying PEG or other linkers. These formats differ in coupling workflow, spacer length and effective molecular weight.
Compare neighboring reagents in our specialty research chemicals.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What reaction is DBCO-acid used for?
The DBCO group is used for strain-promoted azide-alkyne cycloaddition (SPAAC), a copper-free click reaction.
Is DBCO-acid the same as DBCO-NHS ester?
No. DBCO-acid has a carboxylic acid and normally requires activation before amide coupling; DBCO-NHS ester is preactivated.
What should be checked before conjugation?
Confirm the required DBCO derivative, linker length, activation method and compatibility of the target molecule with the conjugation conditions.