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Fmoc-Lys(Dde)-OH is an orthogonally protected L-lysine derivative. Fmoc protects the α-amino group while Dde masks the ε-amino side chain, allowing the two nitrogens to be addressed at different stages of peptide synthesis.
Its practical value is selective side-chain access. Compared with Fmoc-Lys(Mtt)-OH, the side-chain protecting group is removed by a different chemical trigger, so the better choice depends on the complete protecting-group map.
Product Information
| Product Name | Fmoc-Lys(Dde)-OH |
| Catalog No. | AS2083 |
| CAS No. | 150629-67-7 |
| Molecular Formula | C31H36N2O6 |
| Molecular Weight | 532.63 g/mol |
| Building Block Type | Fmoc-protected L-lysine with epsilon-Dde protection |
| Primary Applications | Orthogonal lysine deprotection; branching; labeling; on-resin side-chain acylation; modified peptide synthesis |
Dde Provides a Distinct Orthogonality
Dde is commonly removed with nucleophilic hydrazine-based conditions while Fmoc chemistry proceeds through base-mediated deprotection. This can allow the lysine side chain to be exposed selectively on resin for branching, labeling or acylation.
Why Protecting-Group Choice Is Sequence-Specific
Hydrazine-sensitive functionality elsewhere in the peptide can make Dde less attractive, while acid-sensitive sequences may favor it over Mtt. We consider the side-chain protecting group a route-design decision rather than a catalog substitution.
Applications After Selective Deprotection
Once the ε-amine is exposed, it can be acylated with linkers, fatty acids, fluorophores, chelators or another peptide segment. Selective lysine handling is therefore useful in branched peptides, probes and site-specific conjugates.
Procurement and QC
PubChem confirms CAS 150629-67-7, C31H36N2O6 and MW about 532.6 g/mol. Confirm L stereochemistry and the Dde protection map; related lysine derivatives can have similar nominal analytical behavior.
For sequences containing several orthogonally protected amines, define the deprotection order before synthesis begins. Alan Scientific can evaluate Dde-based routes through custom modified peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does Dde protect?
Dde protects the lysine ε-amino side chain.
How is Dde different from Mtt?
Dde is typically removed by hydrazine-based nucleophilic conditions, while Mtt is acid-labile.
Why use Fmoc-Lys(Dde)-OH?
It allows selective on-resin exposure of one lysine side-chain amine for modification.
Related Technical Resources
Review Fmoc-SPPS route planning