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R-2-Fmoc-N-Me-aminopimelic acid-1-tert-butyl ester is a stereodefined N-methyl aminopimelic-acid derivative containing Fmoc protection and one tert-butyl-protected carboxyl group.
No reliable CAS number has been confirmed for this aminopimelic-acid derivative. Because aminopimelic acid contains two carboxyl functions, confirm the exact tert-butyl ester position from the lot-specific structure or COA before sequence-specific use.
Product Information
| Product Name | R-2-Fmoc-N-Me-aminopimelic acid-1-tert-butyl ester |
| Catalog No. | AS4186 |
| CAS No. | Not confirmed |
| Molecular Formula | C27H33NO6 |
| Molecular Weight | 467.56 g/mol |
| Building Block Type | Fmoc-protected N-methyl aminopimelic acid mono-tert-butyl ester |
| Primary Applications | Noncanonical dicarboxylic-amino-acid synthesis; side-chain functionalization; constrained peptide design; specialty intermediate chemistry |
A Dicarboxylic Amino-Acid Scaffold Creates Multiple Coupling Options
Aminopimelic-acid derivatives contain a backbone amino center and an additional carboxyl-containing chain. Selective protection determines which carboxyl group is available for peptide, lactam, linker, or other derivatization chemistry.
N-Methylation Changes Backbone Behavior
The N-methyl substituent alters hydrogen-bond donation and increases steric demand at the amino center. If incorporated into a peptide-like backbone, coupling may be more difficult than for an unmethylated analog.
Exact Ester Topology Needs Lot Confirmation
Without a CAS-linked public structure, formula C27H33NO6 and MW 467.56 g/mol cannot establish which carboxyl group is protected. We do not recommend inferring connectivity from shorthand naming alone.
Procurement and QC
Because connectivity cannot be established from formula and molecular weight alone, confirm R stereochemistry, Fmoc protection, N-methylation, the exact tert-butyl ester position, the remaining free carboxyl group and lot-specific analytical identity.
Before synthesis, provide the lot structure or supplier COA so the desired connectivity can be reviewed for custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
R-2-Fmoc-N-Me-aminopimelic acid-1-tert-butyl ester MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Does AS4186 have a confirmed CAS number?
No reliable CAS number has been confirmed. Identity should be verified using the exact protected aminopimelic-acid structure and lot-specific analytical documentation.
Why must the tert-butyl ester position be confirmed?
Aminopimelic acid has more than one carboxyl group, and protection position determines connectivity and downstream reactivity.
What does N-Me change?
It methylates the amino nitrogen and can alter both peptide conformation and coupling efficiency.
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