$861.00 - $2584.00
Fmoc-N-Me-Asp(OAll)-OH combines backbone N-methylation with allyl protection of the Asp side-chain carboxyl group. The α-carboxyl remains available for peptide-bond formation.
The OAll group is valuable when the side-chain acid must be exposed orthogonally on resin while many acid-labile protecting groups remain intact.
Product Information
| Product Name | Fmoc-N-Me-Asp(OAll)-OH |
| Catalog No. | AS4165 |
| CAS No. | 2298323-86-9 |
| Molecular Formula | C23H23NO6 |
| Molecular Weight | 409.44 g/mol |
| Material / Building Block Type | Fmoc-protected N-methyl Asp side-chain allyl ester |
| Primary Applications | Backbone N-methyl peptide synthesis; orthogonal side-chain deprotection; lactam/cyclization strategies; branched or modified peptide synthesis |
Application Scope in Orthogonal Side-Chain Chemistry
Selective removal of an allyl ester can expose the Asp side-chain carboxyl for lactam cyclization, linker installation or other on-resin derivatization. The N-methyl residue simultaneously changes backbone conformation and hydrogen-bond donation.
Deprotection Sequence and Compatibility
Allyl protection is commonly removed by palladium-mediated chemistry, whereas Fmoc uses base and many other side-chain groups use acid. The complete sequence should be screened for palladium-sensitive motifs or scavenging requirements before committing to the route.
Coupling and QC
N-methyl residues are more sterically demanding during peptide-bond formation. Confirm CAS 2298323-86-9, C23H23NO6, MW 409.44 g/mol, N-methylation and the side-chain OAll ester.
For lactamization or other orthogonal Asp-side-chain modifications, Alan Scientific can support custom cyclic and modified peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does OAll protect?
The Asp side-chain carboxyl group as an allyl ester.
Why use allyl instead of OtBu?
Allyl provides a different, typically palladium-triggered deprotection pathway.
Does N-methylation remain in the final peptide?
Yes.
Related Technical Resources
Read about noncanonical amino-acid design