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Fmoc-Pro-Pro-Pro-OH is a preassembled triproline fragment with an Fmoc-protected N-terminus and a free C-terminal carboxyl group.
Three consecutive prolines create a highly distinctive backbone environment. This fragment is particularly relevant to polyproline-rich motifs and PPII-type conformational research, where repeated proline geometry rather than side-chain chemistry is the design feature.
Product Information
| Product Name | Fmoc-Pro-Pro-Pro-OH |
| Catalog No. | AS4172 |
| CAS No. | 134303-96-1 |
| Molecular Formula | C30H33N3O6 |
| Molecular Weight | 531.61 g/mol |
| Material / Building Block Type | Fmoc-protected Pro-Pro-Pro tripeptide fragment |
| Primary Applications | Polyproline-rich peptide synthesis; PPII-helix motif construction; proline-rich PPI studies; convergent fragment coupling |
Application Scope in Polyproline Motifs
Proline-rich sequences occur in protein-interaction motifs and can adopt polyproline II-like conformations. A Pro3 fragment can support construction of peptide ligands, interaction probes and conformational analogs containing defined consecutive prolines.
Fragment Assembly and Cis/Trans Behavior
Proline peptide bonds can populate cis and trans conformations and may slow conformational equilibration. A preformed fragment fixes sequence composition but does not remove proline-related folding or chromatographic complexity.
Procurement and QC
Confirm CAS 134303-96-1, C30H33N3O6, MW 531.61 g/mol, exact Pro-Pro-Pro chain length and N-terminal Fmoc. LC-MS is useful for excluding Pro2/Pro4 homologs.
For polyproline-rich peptides or interaction motifs, Alan Scientific can provide custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is the main use of a Pro3 fragment?
Assembly of polyproline-rich and conformationally constrained peptide motifs.
Does Pro3 guarantee a single conformation?
No. Proline-rich sequences can still show cis/trans heterogeneity and sequence-dependent structure.
Is the C-terminal carboxyl free?
Yes, allowing further fragment coupling.
Related Technical Resources
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