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Fmoc-N-Me-Asp-NMe2 is an N-methyl aspartic-acid-derived building block whose exact public structure is described as (S)-3-[Fmoc-(methylamino)]-4-(dimethylamino)-4-oxobutanoic acid.
The structural record shows the carboxyl group directly attached to the stereocenter converted to an N,N-dimethylamide, while the CH2-linked Asp side-chain carboxyl remains free. This makes the material a specialized Asp-derived intermediate rather than a routine α-carboxylic-acid SPPS monomer.
Product Information
| Product Name | Fmoc-N-Me-Asp-NMe2 |
| Catalog No. | AS4189 |
| CAS No. | 2430019-25-1 |
| Molecular Formula | C22H24N2O5 |
| Molecular Weight | 396.44 g/mol |
| Building Block Type | Fmoc-protected N-methyl Asp-derived α-dimethylamide / free side-chain acid |
| Primary Applications | N-methyl Asp intermediate chemistry; side-chain carboxyl functionalization; noncanonical peptide design; terminal amide research |
Why the Dimethylamide Topology Matters
A capped α-carboxyl cannot participate in ordinary peptide-chain extension through the standard amino-acid carboxyl group. The remaining free carboxyl lies on the Asp side chain and can support different coupling or derivatization chemistry.
Backbone N-Methylation Is Also Present
The amino nitrogen is N-methylated in addition to being Fmoc-protected. If the residue is incorporated into a peptide-like architecture, this changes backbone hydrogen-bonding and steric behavior.
Do Not Infer a Conventional Asp Building Block from the Shorthand
The name 'Fmoc-N-Me-Asp-NMe2' can be misread as a normal Fmoc-Asp monomer with a minor side-chain modification. The exact CAS-linked structure should therefore be shown or checked during procurement.
Procurement and QC
Confirm CAS 2430019-25-1, formula C22H24N2O5, MW 396.44 g/mol, S configuration, N-methyl substitution, dimethylamide position, and the remaining free carboxyl group.
For specialty Asp-derived architectures, route design can be evaluated through custom noncanonical peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is this a normal Fmoc-Asp free acid for standard SPPS?
No. The α-carboxyl is capped as an N,N-dimethylamide in the CAS-linked structure.
Which carboxyl group remains free?
The CH2-linked Asp side-chain carboxyl remains free.
Is the amino nitrogen N-methylated?
Yes. The product contains an N-methyl amino group protected with Fmoc.
Related Technical Resources
Read about noncanonical peptide building blocks