$1033.00 - $3101.00
Fmoc-O-phospho-L-Tyr-OH (CAS 147762-53-6) belongs to the fmoc-protected phosphotyrosine building block class. It is used in phosphopeptide synthesis with a pre-installed phosphate, particularly where site-defined phosphopeptide synthesis and phosphorylation-mimic research is required.
Use when the final peptide must contain phosphotyrosine directly; phosphate protection state affects handling and coupling strategy. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Fmoc-O-phospho-L-Tyr-OH |
| Catalog No. | AS4221 |
| CAS No. | 147762-53-6 |
| Molecular Formula | C24H22NO8P |
| Molecular Weight | 483.41 g/mol |
| Compound Type | Fmoc-protected phosphotyrosine building block |
| Primary Research Use | Phosphopeptide synthesis with a pre-installed phosphate |
Use in Site-Defined Phosphopeptides
Fmoc-O-phospho-L-Tyr-OH enables direct introduction of a phosphotyrosine-derived residue during peptide assembly. This supports preparation of defined phosphopeptides for recognition, binding and signaling studies without relying on post-synthetic enzymatic phosphorylation.
Phosphate Protection Strategy
The phosphate protection state affects polarity, coupling behavior and cleavage planning. A protected phosphate can simplify chain assembly, whereas a free or partially protected phosphate changes handling and may require additional attention to solubility and counterions.
Selection and QC
Confirm the exact phosphotyrosine protection pattern, stereochemistry, CAS and mass contribution before sequence calculation. For analytical work, phosphate-state identity is as important as nominal peptide purity.
Compare neighboring reagents in our noncanonical amino acids. Full-sequence work is covered under protected peptide building blocks.
Product Documents
MSDS - Fmoc-O-phospho-L-Tyr-OH (AS4221)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is the main application of this product?
It is used to introduce a defined phosphotyrosine-derived residue into a synthetic peptide.
Why does phosphate protection matter?
Protection changes polarity, coupling behavior and the conditions needed to reveal the final phosphate.
Can it replace unmodified Fmoc-Tyr-OH?
Only when the target peptide is designed to contain the phosphorylated or protected-phosphorylated tyrosine state.