$535.00 - $4816.00
Fmoc-Ala(α-cyclopropyl)-OH is an α-substituted alanine analog bearing a cyclopropyl group directly at the backbone stereocenter.
The matched D-configured product Fmoc-D-Ala(α-cyclopropyl)-OH enables stereochemical comparison without changing elemental composition.
Product Information
| Product Name | Fmoc-Ala(α-cyclopropyl)-OH |
| Catalog No. | AS2137 |
| CAS No. | 1926163-87-2 |
| Molecular Formula | C21H21NO4 |
| Molecular Weight | 351.40 g/mol |
| Material / Building Block Type | Fmoc-protected α-cyclopropyl L-alanine |
| Primary Applications | Conformational peptide SAR; α-substituted amino-acid libraries; steric/hydrophobic tuning; noncanonical Fmoc-SPPS |
Application Scope in Conformational SAR
α-Cyclopropyl substitution removes the α-hydrogen, increases steric demand and adds a compact hydrophobic ring. It can be used to probe backbone conformation, protease recognition and target-pocket tolerance.
Coupling Behavior
α-Substitution makes peptide-bond formation more sterically demanding than ordinary Ala. Difficult neighboring residues can amplify that effect, so coupling completion should be monitored.
Procurement and QC
Confirm CAS 1926163-87-2, C21H21NO4, MW 351.40 g/mol and the L-configured α-cyclopropyl Ala identity.
Matched L/D analogs can be synthesized through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Fmoc-Ala(α-cyclopropyl)-OH MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does α-cyclopropyl substitution change?
Backbone sterics, hydrophobicity and conformational freedom.
Is the D analog the same mass?
Yes.
Can standard SPPS be used?
Yes in principle, but steric hindrance can require optimized coupling.
Related Technical Resources
Read about noncanonical amino acids