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(9H-Fluoren-9-yl)methyl (6-aminohexyl)carbamate hydrochloride is the hydrochloride salt of mono-Fmoc-protected 1,6-diaminohexane. It is also commonly described as Fmoc-1,6-diaminohexane HCl or Fmoc-Hmd-HCl.
The Fmoc group provides base-labile protection at one end of the six-carbon diamine while the opposite terminal amine is available in protonated salt form. This makes the reagent useful when a linker must be introduced first and its second amine revealed later under Fmoc-compatible conditions.
Product Information
| Product Name | (9H-Fluoren-9-yl)methyl (6-aminohexyl)carbamate hydrochloride |
| Catalog No. | AS2085 |
| CAS No. | 945923-91-1 |
| Molecular Formula | C21H27ClN2O2 |
| Molecular Weight | 374.90 g/mol |
| Building Block Type | Mono-Fmoc-protected 1,6-diaminohexane hydrochloride |
| Primary Applications | Fmoc-compatible linker synthesis; conjugation; spacer construction; aminohexyl derivatization |
Why the Hydrochloride Salt Matters
The HCl form changes handling, formula and molecular weight relative to the free base. Procurement records can list both CAS 945923-91-1 for the hydrochloride and a different identifier for the free base, so salt state should be confirmed rather than inferred from the shorthand name.
Fmoc as a Linker-Protecting Group
Fmoc can be removed under basic conditions, which is useful when acid-sensitive functionality is already present elsewhere in the molecule. This is the opposite orthogonality from N-Boc-1,6-diaminohexane, where the protecting group is acid-labile.
A Six-Carbon Spacer Changes Final Geometry
The aminohexyl chain can separate a peptide, fluorophore, chelator or small-molecule cargo from the point of attachment. That distance can reduce steric interference, but the added methylene units also increase hydrophobicity and flexibility.
Compare Boc and Fmoc Linker Routes
For an acid-labile alternative, compare N-Boc-1,6-Diaminohexane. Choosing between Boc and Fmoc should be based on the orthogonality required by the complete synthetic route.
Procurement and QC Considerations
Confirm CAS 945923-91-1, formula C21H27ClN2O2 and MW 374.90 g/mol for the hydrochloride. The free base has a lower molecular weight, so formula and salt state should be matched to the actual lot documentation.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
(9H-Fluoren-9-yl)methyl (6-aminohexyl)carbamate hydrochloride MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is this the same as free-base Fmoc-1,6-diaminohexane?
No. This product is the hydrochloride salt and has a different formula and molecular weight.
Why use Fmoc on a diamine linker?
It allows one amine to be revealed later under base-labile conditions.
Can this linker be used in peptide conjugation?
Yes, when the protection strategy and coupling chemistry are compatible with the complete construct.
Related Technical Resources
Discuss linker-containing custom peptides