$213.00 - $1090.00
Fmoc-L-Dap(N3)-OH (CAS 684270-46-0) is supplied as an Fmoc-protected azide-functional amino-acid building block. In research synthesis, it is most relevant to azide-functional peptide synthesis and bioorthogonal derivatization and click-compatible peptide functionalization and orthogonal labeling.
Use when a compact azide handle is required; confirm that the complete synthesis and workup preserve the azide functionality. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Fmoc-L-Dap(N3)-OH |
| Catalog No. | AS4277 |
| CAS No. | 684270-46-0 |
| Molecular Formula | C18H16N4O4 |
| Molecular Weight | 352.35 g/mol |
| Compound Type | Fmoc-protected azide-functional amino-acid building block |
| Primary Research Use | Azide-functional peptide synthesis and bioorthogonal derivatization |
Functional Handle in Peptide Synthesis
Fmoc-L-Dap(N3)-OH carries an azide while retaining a peptide-compatible protected amino-acid framework. This enables a reactive handle to be placed at a defined residue position during sequence assembly.
Post-Synthetic Derivatization
After peptide synthesis, the installed handle can support bioorthogonal azide chemistry. The downstream conjugation strategy should be chosen with the complete peptide sequence, solvent compatibility and other reactive groups in mind.
Selection and Handling
Confirm the location and type of the reactive handle rather than treating all click-capable amino acids as equivalent. Light, reducing conditions, metals or nucleophiles can affect some functional groups differently.
Additional chemistry is available in the specialty amino acid set. For synthesis planning beyond the building block, see specialty SPPS building blocks.
Product Documents
MSDS - Fmoc-L-Dap(N3)-OH (AS4277)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Frequently Asked Questions
What functional handle does this building block introduce?
It introduces the azide or alkyne handle encoded in the product structure at a defined residue position.
Can the handle be used after peptide synthesis?
Yes, provided the synthesis and cleavage conditions preserve the reactive group.
Why is exact handle identity important?
Aryl azides, alkyl azides and terminal alkynes can have different stability and downstream reaction behavior.