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Boc-Lys-OH is Nα-Boc-L-lysine. The α-amino group is Boc-protected, while the lysine ε-amino side chain remains free.
That free ε-amine is the defining feature. This material should not be treated as a routine fully protected lysine monomer for linear peptide synthesis, because the unprotected side-chain amine can participate in acylation unless the route is deliberately designed around it.
Product Information
| Product Name | Boc-Lys-OH |
| Catalog No. | AS2029 |
| CAS No. | 13734-28-6 |
| Molecular Formula | C11H22N2O4 |
| Molecular Weight | 246.30 g/mol |
| Building Block Type | Nα-Boc-L-lysine with free ε-amino group |
| Primary Applications | Selective lysine side-chain derivatization; protected intermediate synthesis; branching chemistry; solution-phase peptide and conjugation research |
Why a Free ε-Amine Can Be Useful
Selective protection of the α-amino group leaves the side-chain amine available for derivatization. This can support preparation of ε-acylated lysine analogs, branch points, linkers, labels, or other customized lysine building blocks.
Why It Is Not a Drop-In Standard Lysine Reagent
In ordinary peptide elongation, a free ε-amine can compete with the intended backbone amine or react during activated-carboxyl chemistry. Additional protection is normally required if the side chain must remain inert throughout chain assembly.
Boc Protection and Route Design
Boc on the α-amino group is acid-labile. If the side chain is derivatized first, the newly installed ε-substituent should be chosen with the later Boc-removal and coupling sequence in mind. The SPPS practical guide is useful when converting a selectively protected lysine intermediate into a peptide-ready reagent.
Procurement and QC
Confirm CAS 13734-28-6, C11H22N2O4, MW 246.30 g/mol, L configuration, Nα-Boc protection, and a free ε-NH2 group. Protection position is more important than the shorthand 'Boc-Lys' alone.
For peptides requiring ε-lipidation, labeling, branching, or another lysine-side-chain modification, Alan Scientific can plan the building-block and sequence chemistry together through custom modified peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Which lysine amine is Boc-protected?
The α-amino group is Boc-protected.
Is the ε-amino group protected?
No. The side-chain ε-amino group is free.
Can Boc-Lys-OH be used directly like a standard fully protected lysine monomer?
Not without considering side-chain reactivity; the free ε-amine may require derivatization or additional protection.
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