$457.14 - $1371.43
Fmoc-L-4-AzidoPhe-OH (CAS 163217-43-4) belongs to the fmoc-protected azidophenylalanine building block class. It is used in photoaffinity and azide-functional peptide synthesis, particularly where photo-crosslinking, labeling and azide-enabled derivatization is required.
Use when an aryl azide is intentionally introduced; account for light sensitivity and the chosen downstream photochemistry or conjugation step. Before substitution into an established synthesis, compare stereochemistry, protecting-group orthogonality and downstream deprotection requirements.
Product Information
| Product Name | Fmoc-L-4-AzidoPhe-OH |
| Catalog No. | AS4229 |
| CAS No. | 163217-43-4 |
| Molecular Formula | C24H20N4O4 |
| Molecular Weight | 428.45 g/mol |
| Compound Type | Fmoc-protected azidophenylalanine building block |
| Primary Research Use | Photoaffinity and azide-functional peptide synthesis |
Functional Handle in Peptide Synthesis
Fmoc-L-4-AzidoPhe-OH carries an aryl azide while retaining a peptide-compatible protected amino-acid framework. This enables a reactive handle to be placed at a defined residue position during sequence assembly.
Post-Synthetic Derivatization
After peptide synthesis, the installed handle can support photoaffinity or azide-directed derivatization. The downstream conjugation strategy should be chosen with the complete peptide sequence, solvent compatibility and other reactive groups in mind.
Selection and Handling
Confirm the location and type of the reactive handle rather than treating all click-capable amino acids as equivalent. Light, reducing conditions, metals or nucleophiles can affect some functional groups differently.
Compare neighboring reagents in our noncanonical amino acids. Full-sequence work is covered under protected peptide building blocks.
Product Documents
MSDS - Fmoc-L-4-AzidoPhe-OH (AS4229)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What functional handle does this building block introduce?
It introduces the azide or alkyne handle encoded in the product structure at a defined residue position.
Can the handle be used after peptide synthesis?
Yes, provided the synthesis and cleavage conditions preserve the reactive group.
Why is exact handle identity important?
Aryl azides, alkyl azides and terminal alkynes can have different stability and downstream reaction behavior.