$365.00 - $1863.00
Fmoc-Gln(Xan)-OH is Nα-Fmoc-Nγ-xanthyl-L-glutamine. The xanthyl (Xan) group protects the glutamine side-chain amide nitrogen during peptide synthesis while the α-amino group remains compatible with Fmoc-SPPS.
This building block is most relevant when glutamine side-chain chemistry becomes a synthesis risk rather than when a routine unprotected side-chain Gln reagent is already performing well.
Product Information
| Product Name | Fmoc-Gln(Xan)-OH |
| Catalog No. | AS4180 |
| CAS No. | 185031-81-6 |
| Molecular Formula | C33H28N2O6 |
| Molecular Weight | 548.60 g/mol |
| Material / Building Block Type | Fmoc-protected Nγ-xanthyl L-glutamine |
| Primary Applications | Gln-containing peptide synthesis; suppression of Gln side-chain dehydration; difficult-sequence SPPS; acid-labile side-chain protection |
Application Scope in Gln-Rich and Difficult Sequences
Xan-protected Gln can be useful in long, aggregation-prone or impurity-sensitive sequences where side-chain dehydration or other Gln-derived byproducts complicate purification. It provides a route option for controlling side-chain amide chemistry during activation.
Xanthyl Protection and Deprotection Window
The Xan group masks the side-chain amide nitrogen and is acid-labile. It should be evaluated against all other acid-sensitive groups in the sequence so that final cleavage and side-chain deprotection remain compatible.
Analytical Identity and Storage
Confirm CAS 185031-81-6, C33H28N2O6, MW 548.60 g/mol and Nγ-xanthyl protection. Major supplier data list sealed dry storage at 2-8°C and classify the material as H302/H315/H319.
Procurement and QC Considerations
For Gln-rich targets or routes with recurrent Gln side products, Alan Scientific can evaluate the protection strategy through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does Xan protect?
It protects the glutamine side-chain amide nitrogen.
Why use Xan-protected Gln?
It can reduce selected Gln side reactions during activation and chain assembly.
Is Xan removed during final cleavage?
It is acid-labile and is normally removed under an appropriately designed final deprotection regime.