Fmoc-D-Aph(Cbm)-OH is a D-phenylalanine derivative bearing a para-carbamoylamino substituent on the aromatic ring. The Fmoc group protects the α-amino function while the substituted aryl group remains the defining side-chain feature.

The residue combines D stereochemistry with a polar aromatic urea-like functionality, making it useful for testing aromatic binding contacts without relying on a simple hydrophobic phenylalanine analog.

Product Information

Application Scope in Functional Aromatic SAR

The para-carbamoylamino group adds hydrogen-bond donors/acceptors and polarity to a phenylalanine-like side chain. It can be used to probe solvent exposure, receptor-pocket hydrogen bonding and aromatic recognition in peptide or peptidomimetic series.

D Stereochemistry as a Separate Variable

The D configuration can alter backbone geometry and protease recognition independently of the aromatic substitution. Matched D/L studies should therefore be designed carefully; broader options are available in D-Form Amino Acids.

Procurement and QC

Confirm CAS 324017-22-3, C25H23N3O5, MW 445.48 g/mol and D/(2R) stereochemistry. PubChem identifies the side chain as 4-(carbamoylamino)phenyl rather than a generic protected aniline.

For functional aromatic D-residue analogs, Alan Scientific can prepare sequence-matched peptides through custom peptide synthesis.

Product Documents

A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.

Fmoc-D-Aph(Cbm)-OH MSDS

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What does Aph(Cbm) represent?

A para-carbamoylamino-substituted phenylalanine derivative.

Can LC-MS prove D stereochemistry?

No.

What is the main application?

Peptide SAR where both D configuration and a polar functionalized aromatic side chain are being tested.

Research Use Only.