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Fmoc-Cha-OH (CAS 135673-97-1) is a Protected amino-acid / peptidomimetic building block selected for a constrained or cycloalkyl side chain used to probe hydrophobic packing and conformation. This positions it within peptide, peptidomimetic and medicinal-chemistry synthesis.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | Fmoc-Cha-OH |
| Catalog No. | AS4215 |
| CAS No. | 135673-97-1 |
| Molecular Formula | C24H27NO4 |
| Molecular Weight | 393.48 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Functional Role of the Residue
Fmoc-Cha-OH provides a constrained or cycloalkyl side chain used to probe hydrophobic packing and conformation. In a peptide or small-molecule route, this feature should be introduced deliberately because it can change both synthetic behavior and final molecular properties.
Route Compatibility
Evaluate coupling conditions and deprotection orthogonality with the neighboring residues and other protecting groups already present. The most reliable route is the one designed around the full protection pattern, not an isolated building block.
Browse the unusual residue building blocks for related structures. Complex sequence work can also use specialty peptide building blocks.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What distinguishes Fmoc-Cha-OH in synthesis?
Its intended role is peptide, peptidomimetic and medicinal-chemistry synthesis, with the exact residue or functional-group state defined by the product structure.
Why check the protection map for Fmoc-Cha-OH?
In Fmoc-Cha-OH, the protection state determines which functions remain reactive and which deprotection conditions can be used later in the route.