ent-Amyloid β-Protein (1-42) is a synthetic peptide composed entirely of D-amino acid enantiomers, representing the mirror-image counterpart of the native L-amino acid-based Aβ(1-42) peptide associated with Alzheimer’s disease. This "ent-" (enantiomeric) variant retains the same amino acid sequence as wild-type Aβ(1-42) but with each residue in its D-configuration, disrupting the natural secondary structure formation and hydrophobic interactions critical for aggregation. Unlike the native peptide, which readily forms toxic oligomers and fibrils, ent-Aβ(1-42) exhibits reduced propensity to assemble into pathological aggregates due to its altered stereochemistry, serving as a valuable control in studies to investigate the role of amino acid chirality in Aβ misfolding, neurotoxicity, and receptor binding. In research, it helps validate the specificity of biological interactions, such as antibody recognition or cellular uptake, by distinguishing effects driven by primary sequence versus stereochemical configuration. While not naturally occurring, this enantiomeric variant highlights the importance of chiral symmetry in Aβ’s pathogenicity, supporting mechanistic studies of amyloidosis and the development of therapies targeting stereoselective interactions.

Chemical Formula: C203H311N55O60S

Molecular Weight: 4514.14

Sequence: D-Asp-D-Ala-D-Glu-D-Phe-D-Arg-D-His-D-Asp-D-Ser-Gly-D-Tyr-D-Glu-D-Val-D-His-D-His-D-Gln-D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala-D-Glu-D-Asp-D-Val-Gly-D-Ser-D-Asn-D-Lys-Gly-D-Ala-D-Ile-D-Ile-Gly-D-Leu-D-Met-D-Val-Gly-Gly-D-Val-D-Val-D-Ile-D-Ala

Purity: From crude to 98%

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