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DDe-OH, more commonly styled Dde-OH, is 2-acetyldimedone, a peptide-synthesis reagent used to introduce the Dde amine protecting group. Dde protection is valued in Fmoc solid-phase peptide synthesis because it can provide an orthogonal, hydrazine-labile protection strategy for amino functions.
This makes Dde chemistry particularly useful when a synthesis requires selective exposure of a lysine side-chain amine while the growing peptide remains attached to resin and other common protecting groups remain in place.
Product Information
| Product Name | DDe-OH |
| Preferred Literature Style | Dde-OH |
| Chemical Name | 2-Acetyldimedone |
| Catalog No. | AS3010 |
| CAS No. | 94142-97-9 |
| Molecular Formula | C10H14O3 |
| Molecular Weight | 182.22 g/mol |
| Primary Use | Introduction of the Dde amine protecting group |
Dde as an Orthogonal Protecting Group
Orthogonal protection allows one functional group to be revealed without globally deprotecting the molecule. In Fmoc-SPPS, Dde-type protection is frequently used on lysine or other amino-containing side chains when selective on-resin modification is required.
Dde can be removed with hydrazine-based conditions selected to preserve many groups used in standard Fmoc/tBu peptide synthesis. This creates a free amine for subsequent acylation, branching, cyclization, labeling or conjugation.
Applications in Branched and Modified Peptides
Dde protection is relevant to orthogonal lysine protection, branched peptide synthesis, multiple-antigen peptides, peptide labeling, lipidation, biotinylation and site-selective conjugation.
The reagent itself is used to install a protecting group and is not a direct biological assay compound. The modified final peptide can subsequently be tested according to its intended biochemical or biological application.
Dde vs ivDde
Dde and ivDde are related hydrazine-labile amino protecting groups but are not chemically identical. ivDde is more sterically substituted and can provide different stability during repeated Fmoc deprotection cycles.
Customers should therefore order by the exact protecting-group reagent and CAS rather than treating Dde and ivDde as synonyms.
Purchasing and QC Considerations
Confirm CAS 94142-97-9, the identity 2-acetyldimedone, reagent purity and storage condition. Novabiochem identifies this compound specifically as a reagent for introduction of the Dde protecting group and recommends refrigerated storage.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Dde-OH used for?
It is used to introduce the Dde protecting group onto amines in peptide-synthesis workflows.
How is Dde removed?
Dde is commonly removed using hydrazine-based conditions selected for orthogonal deprotection in Fmoc-SPPS.
Is Dde the same as ivDde?
No. They are related protecting groups with different structures and stability profiles.
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