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PyAOP (CAS 156311-83-0) belongs to the phosphonium peptide coupling reagent class. It is used in amide-bond formation and peptide coupling, particularly where amide formation, difficult coupling and peptide cyclization workflows is required.
Select it as a coupling reagent; it is not an amino-acid building block. Reaction optimization still depends on substrate, base and solvent. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | PyAOP |
| Catalog No. | AS4225 |
| CAS No. | 156311-83-0 |
| Molecular Formula | C17H27F6N7OP2 |
| Molecular Weight | 521.39 g/mol |
| Compound Type | Phosphonium peptide coupling reagent |
| Primary Research Use | Amide-bond formation and peptide coupling |
PyAOP in Amide-Bond Formation
PyAOP is a phosphonium coupling reagent used to activate carboxylic acids for reaction with amines. In peptide workflows it is associated with efficient amide-bond formation and is often considered for demanding couplings or cyclization-oriented routes.
Why the PyAOP Acronym Matters
Researchers commonly search this compound by the acronym PyAOP rather than by the full phosphonium salt name. The exact CAS number 156311-83-0, molecular formula and counterion remain important procurement checks because related phosphonium coupling reagents have similar names.
Reaction Planning
Coupling outcome still depends on substrate concentration, base, solvent, stoichiometry and sequence context. PyAOP should be evaluated as part of the complete activation system rather than treated as a universal replacement for every peptide-coupling reagent.
Compare neighboring reagents in our amide-forming reagents. Full-sequence work is covered under current small-molecule range.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is PyAOP used for?
PyAOP is used as a phosphonium coupling reagent for amide-bond formation, including peptide synthesis.
Is PyAOP an amino-acid building block?
No. It is a coupling reagent used to activate carboxylic acids for reaction with amines.
Why search by CAS as well as PyAOP?
The CAS number helps distinguish PyAOP from related phosphonium coupling reagents with similar acronyms and structures.