[D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11) is a modified analog of the octapeptide Substance P (4-11), incorporating D-proline (D-Pro) at position 4, D-tryptophan (D-Trp) at positions 7 and 9, and norleucine (Nle) at position 11. These substitutions enhance its stability, resistance to enzymatic degradation, and binding specificity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor activation mechanisms, and explore therapeutic potential for analgesic and anti-inflammatory drug development.

Chemical Formula: C58H77N13O10

Molecular Weight: 1116.34

Sequence: D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Nle-NH2

Purity: From crude to 98%

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Research Use Only