Orexin B, human is an endogenous neuropeptide produced in the hypothalamus, consisting of 33 amino acids with high structural conservation across mammalian species. It acts as a ligand for Orexin 1 (OX1) and Orexin 2 (OX2) receptors, mediating critical roles in arousal, appetite regulation, energy homeostasis, and stress responses in humans. This peptide plays a central role in sleep-wake cycles, feeding behavior, and metabolic regulation. In pharmacological research, human Orexin B serves as a tool to investigate receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for disorders like insomnia, narcolepsy, obesity, and neurodegenerative conditions. Its cross-species conservation underscores its evolutionary significance and utility in translational studies, offering insights into Orexin signaling pathways and drug development for human health.

Chemical Formula: C123H212N44O35S

Molecular Weight: 2899.40

Sequence: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Purity: From crude to 98%

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