[D-Arg1,D-Pro2,D-Phe7,D-His9]-Substance P is a synthetic analog of the naturally occurring neuropeptide Substance P, featuring four D-amino acid substitutions (D-Arg at position 1, D-Pro at 2, D-Phe at 7, and D-His at 9) to enhance stability and modulate receptor interactions. As a member of the tachykinin family, native Substance P binds to neurokinin 1 (NK1) receptors, playing a key role in pain transmission, inflammation, and immune responses. The D-amino acid modifications in this analog increase resistance to proteolytic degradation, prolonging its biological half-life, while altering its binding affinity and selectivity for NK1 receptors. In research, [D-Arg1,D-Pro2,D-Phe7,D-His9]-Substance P is used as a tool to investigate NK1 receptor-mediated signaling pathways, particularly in models of pain, neuroinflammation, and respiratory disorders. It also serves as a lead compound for developing more stable therapeutics targeting NK1 receptors, with potential applications in conditions like chronic pain, depression, or asthma. By combining structural rigidity with enhanced pharmacological properties, this analog highlights the utility of peptide modification in optimizing bioactivity for both research and clinical purposes.

Chemical Formula: C67H102N20O13S

Molecular Weight: 1427.75

Sequence: D-Arg-D-Pro-Lys-Pro-Gln-Gln-D-Phe-Phe-D-His-Leu-Met-NH2

Purity: From crude to 98%

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