[D-Pro2,D-Phe7,D-Trp9]-Substance P is a synthetic analog of Substance P with D-isomer substitutions at positions 2, 7, and 9: D-proline replaces the native amino acid at position 2, D-phenylalanine at position 7, and D-tryptophan at position 9. These modifications enhance its stability, resistance to enzymatic degradation, and binding affinity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor specificity, and explore therapeutic potential for analgesic and anti-inflammatory drug development.

Chemical Formula: C72H105N19O13S

Molecular Weight: 1476.82

Sequence: Arg-D-Pro-Lys-Pro-Gln-Gln-D-Phe-Phe-D-Trp-Leu-Met-NH2

Purity: From crude to 98%

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Research Use Only