[Tyr8,Nle11] Substance P is a synthetic analog of Substance P. In this analog, tyrosine (Tyr) replaces the original amino acid at position 8, and norleucine (Nle) substitutes for the native residue at position 11. These modifications significantly enhance its stability and resistance to enzymatic degradation. It also shows improved binding affinity to neurokinin - 1 (NK - 1) receptors. Retaining the bioactivity of Substance P, it plays a role in modulating pain signaling, inflammatory responses, and immune functions. In pharmacological research, [Tyr8,Nle11] Substance P serves as a crucial tool to explore structure - activity relationships, understand receptor specificity, and investigate potential therapeutic applications for analgesic and anti - inflammatory drug development.

Chemical Formula: C64H100N18O14

Molecular Weight: 1345.62

Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Tyr-Gly-Leu-Nle-NH2

Purity: From crude to 98%

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