[D-Arg1,D-Phe5,D-Trp7,11]-Substance P is a synthetic analog of Substance P with D-isomer substitutions at positions 1, 5, 7, and 11: D-arginine replaces the native amino acid at position 1, D-phenylalanine at position 5, and D-tryptophan at positions 7 and 11. These modifications enhance its resistance to enzymatic degradation, improve stability, and optimize binding affinity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate receptor specificity, structure-activity relationships, and explore therapeutic potential for analgesic and anti-inflammatory applications.

Chemical Formula: C75H101N19O12

Molecular Weight: 1460.76

Sequence: D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-Gly-Leu-D-Trp-NH2

Purity: From crude to 98%

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Research Use Only