[D-Glu5,D-Trp7,9,10]-Substance P (5-11) is a modified analog of the heptapeptide Substance P (5-11), incorporating D-glutamic acid (D-Glu) at position 5 and D-tryptophan (D-Trp) at positions 7, 9, and 10. These substitutions enhance its stability, resistance to enzymatic degradation, and binding specificity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor activation mechanisms, and explore therapeutic potential for analgesic and anti-inflammatory drug development.

Chemical Formula: C57H66N12O10S

Molecular Weight: 1111.30

Sequence: D-Glu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2

Purity: From crude to 98%

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Research Use Only