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Ac-Gln-OH (Nα-acetyl-L-glutamine; CAS 2490-97-3) is an N-acetylated glutamine derivative also known as aceglutamide. N-acetylation removes the free alpha-amino functionality while retaining the glutamine side-chain amide and carboxyl group.
Product Information
| Product Name | Ac-Gln-OH |
| Catalog No. | AS2019 |
| CAS No. | 2490-97-3 |
| Molecular Formula | C7H12N2O4 |
| Molecular Weight | 188.18 g/mol |
| Sequence / Identity | Ac-Gln |
| Synonym | Nα-acetyl-L-glutamine; aceglutamide |
| Primary Research Use | biochemical reference compound |
Use as an Acetyl-Amino-Acid Reference
Nα-acetyl-L-glutamine is a defined small molecule that can be used in analytical and biochemical studies of acetylated amino-acid derivatives. For quantitative work, the lot-specific assay basis and water content are more important than broad pharmacological descriptions.
Analytical Identity and Method Development
Short peptides are often purchased as reference compounds because exact sequence, terminal state and stereochemistry can influence retention, ionization and fragmentation. When peak assignment matters, use the exact compound identity rather than relying only on nominal molecular mass.
Procurement and QC Considerations
For research use, match the requested purity and documentation to the experiment. Analytical or quantitative studies benefit from lot-specific HPLC and MS data, while metabolomics or sequence-isomer work may require additional identity controls.
Related materials can be reviewed under impurity and research standards.
Analytical Use and Lot Documentation
For qualitative identification or method development, sequence identity, expected molecular mass and chromatographic purity may be sufficient. Quantitative use can require additional lot-specific information such as an assigned purity or content basis and a preparation protocol appropriate to the analytical method.
HPLC purity and mass-spectrometric identity answer different questions and should not be treated as interchangeable. Solubility and solution stability should also be validated at the concentration and solvent conditions used in the experiment when no product-specific solution data are available.
Product Documents
The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Ac-Gln-OH?
It is Nα-acetyl-L-glutamine; aceglutamide, a defined research compound with sequence or structural identity Ac-Gln.
What is the main value of this product?
Its main value is as a chemically defined reference for biochemical reference compound.
What should be checked before quantitative use?
Confirm lot-specific identity, purity basis and analytical documentation appropriate to the method.