α-Conotoxin IMI is a neuroactive peptide derived from the venom of the cone snail Conus imitator, specifically targeting nicotinic acetylcholine receptors (nAChRs). This peptide binds to the ligand-binding sites of neuronal and muscle-type nAChR subtypes to block acetylcholine-mediated activation. By disrupting cholinergic signaling, α-Conotoxin IMI inhibits neuromuscular transmission and neuronal communication, serving as a key component of the snail’s predatory strategy. In research, it is used as a molecular tool to investigate the structural and functional properties of nAChRs, particularly in understanding receptor subtypes involved in pain pathways, muscle function, and neurological disorders. Its high specificity and affinity for nAChRs make it a valuable lead for developing therapeutic agents targeting nAChR-related conditions, such as chronic pain or Alzheimer’s disease, while offering insights into the evolutionary precision of venom peptides for modulating cellular signaling.

Chemical Formula: C52H74N20O15S4

Molecular Weight: 1347.58

Sequence: Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2(Disulfidebridge:Cys2-Cys8,-Cys3-Cys12)

Purity: From crude to 98%

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