α-Conotoxin GI is a potent neurotoxic peptide derived from the venom of the cone snail Conus geographus, targeting nicotinic acetylcholine receptors (nAChRs) with high specificity. Composed of 13 amino acids stabilized by two disulfide bridges, this peptide acts as a competitive antagonist, binding to the ligand-binding sites of muscle-type (α1β1γδ/ε) and certain neuronal nAChR subtypes to block acetylcholine-mediated receptor activation. By disrupting cholinergic signaling, α-Conotoxin GI inhibits neuromuscular transmission and neuronal communication, serving as a key component of the snail’s predatory strategy. In research, it is used as a molecular tool to dissect the structure-function relationships of nAChRs, particularly in elucidating receptor subtypes involved in pain modulation, muscle disorders, and neurological conditions. Its exceptional selectivity and affinity for nAChRs also position it as a valuable lead for developing therapeutic agents targeting nAChR-related diseases, such as chronic pain or Alzheimer’s, while offering insights into the evolutionary adaptations of venom peptides for precise molecular targeting.

Chemical Formula: C55H76N20O18S4

Molecular Weight: 1433.63

Sequence: Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2(Disulfidebridge:Cys2-Cys7,-Cys3-Cys13）

Purity: From crude to 98%

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