Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina), known for its role in regulating gastric secretion and smooth muscle contraction. In mammals, it acts as a ligand for gastrin-releasing peptide receptors (GRPR), which are often overexpressed in cancer cells, particularly in prostate, breast, and lung tumors. This peptide’s high affinity for GRPR makes it a valuable tool in oncology research for developing targeted diagnostic and therapeutic strategies. Bombesin-based analogs are used in molecular imaging to visualize GRPR-positive tumors and as carriers for delivering cytotoxic agents to cancer cells, leveraging its receptor-binding specificity to enhance precision in cancer management. Additionally, it serves as a model peptide for studying peptide-receptor interactions and signal transduction pathways involved in cell proliferation and survival.

Chemical Formula: C71H111N24O18S

Molecular Weight: 1619.86

Sequence: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Purity: From crude to 98%

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