Boc-R-3-OH-PHA is an R-configured hydroxyphenyl β-amino-acid derivative, independently indexed as Boc-3-hydroxy-D-β-phenylalanine / (R)-3-(Boc-amino)-3-(3-hydroxyphenyl)propionic acid.

It provides the stereochemical counterpart needed for matched β-amino-acid studies where both backbone configuration and phenolic orientation can influence activity.

Product Information

Application Scope in Matched-Pair β-Peptide SAR

R/S comparisons can help distinguish stereochemical effects from the shared meta-hydroxyphenyl chemistry. Applications include peptidomimetic ligand design, protease-resistance studies and conformational screening.

Phenolic Functionality

The free meta-phenol adds hydrogen-bonding and derivatization potential. It also changes polarity relative to unsubstituted β-phenylalanine analogs.

Procurement and QC

Confirm CAS 500788-89-6, C14H19NO5, MW 281.30 g/mol and R configuration. Chiral identity requires more than mass spectrometry.

For stereochemical β-amino-acid series, Alan Scientific can support custom peptide synthesis.

Product Documents

A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.

Boc-R-3-OH-PHA MSDS

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What does R specify?

The stereochemistry of the β-amino-acid center.

Is the phenol protected?

No additional phenol protecting group is indicated.

Why compare R and S analogs?

To identify stereochemistry-dependent binding or conformational effects.

Related Technical Resources

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