Boc-(R)-3-amino-2-methylpropanoic acid is a Boc-protected β-amino-acid derivative in which the amino group is on C3 and the stereocenter lies at the adjacent methyl-substituted carbon.

Moving the amino group away from the α-carbon creates a β-amino-acid backbone, increasing the number of rotatable bonds between consecutive amide units when incorporated into peptide-like structures.

Product Information

Application Scope in β-Peptide Design

β-Amino acids are used to build protease-resistant peptidomimetics, backbone-homologated analogs and conformationally distinct libraries. The methyl substituent provides a compact stereochemical bias without a bulky aromatic side chain.

Coupling and Route Planning

Boc protects the β-amino group during carboxyl activation. β-Amino-acid oligomers can show folding and coupling behavior different from α-peptides, so route conditions should be optimized for the actual sequence.

Procurement and QC

Confirm CAS 132696-45-8, C9H17NO4, MW 203.24 g/mol and R configuration. Public supplier safety data list H302/H315/H319/H332/H335.

For β-peptide or mixed α/β sequences, Alan Scientific can provide custom peptidomimetic synthesis.

Product Documents

A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.

Boc-(R)-3-amino-2-methylpropanoic acid MSDS

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Is this an α-amino acid?

No. The amino group is on C3, making it a β-amino-acid derivative.

Why use β-amino acids?

To alter backbone geometry and often improve resistance to conventional proteases.

Can LC-MS establish R configuration?

No.

Related Technical Resources

Read about noncanonical amino acids

Research Use Only.