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Boc-(R)-2-thienylglycine is the R-configured member of the 2-thienylglycine enantiomer pair. It introduces a compact sulfur-containing heteroaromatic substituent while reversing the alpha-carbon configuration relative to the S analog.
For procurement, we recommend reviewing the CAS number and stereochemical designation before comparing price or assay. A COA showing only HPLC purity and LC-MS identity does not by itself prove enantiomeric identity. When the stereochemistry drives the experiment, request supporting chiral or optical information when available.
Product Information
| Product Name | Boc-(R)-2-thienylglycine |
| Catalog No. | AS4045 |
| CAS No. | 74562-03-1 |
| Molecular Formula | C11H15NO4S |
| Molecular Weight | 257.30 g/mol |
| Chemical Identity | (R)-configured 2-thienylglycine derivative with Boc-protected amino function |
| Primary Applications | Stereochemical SAR, peptidomimetics and heteroaromatic amino-acid incorporation |
Using the R enantiomer as a control
The R building block is especially informative when a project needs to separate chemical effects of the thiophene ring from stereochemical recognition. Matched R/S analogs can reveal whether activity changes arise from heteroaromatic substitution itself or from how the residue is oriented in the target-bound conformation.
Identity and coupling control
The R and S products have the same formula and molecular weight. CAS 74562-03-1 identifies the R material, while CAS 40512-56-9 identifies the S analog. Coupling conditions should limit unnecessary base exposure or prolonged activation when preservation of configuration is critical.
Procurement and QC Considerations
Confirm the CAS number, drawn structure, assay and stereochemical identity. Because the enantiomeric pair has the same formula and mass, a mass match alone does not establish the correct product.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
MSDS_AS4045_Boc-R-2-thienylglycine
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is the main difference between the R and S thienylglycine products?
They have opposite configuration at the alpha carbon and therefore present the 2-thienyl group differently in three dimensions.
Why can both enantiomers show the same LC-MS mass?
Enantiomers have identical molecular formula and mass.
Can Boc-(R)-2-thienylglycine be used in peptidomimetics?
Yes. It is commonly considered for non-natural residue scanning and heteroaromatic peptidomimetic design.
Related Technical Resources
Browse related specialty peptide building blocks for protected amino acids, fragments and noncanonical synthesis intermediates.
For complete sequence work using this chemistry, see our stereochemical peptide synthesis.