$542.86 - $1628.57
Boc-Glu-OFm (CAS 133906-29-3) is supplied as a Boc/fluorenylmethyl-protected glutamic acid intermediate. In research synthesis, it is most relevant to orthogonal glutamate protection, side-chain functionalization and cyclic-peptide route development and differential glutamate carboxyl protection, side-chain attachment and convergent peptide chemistry.
Use this protection pattern when the route requires selective access to glutamate functionality; confirm which carboxyl group is protected in the exact structure before coupling or cyclization. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.
Product Information
| Product Name | Boc-Glu-OFm |
| Catalog No. | AS4212 |
| CAS No. | 133906-29-3 |
| Molecular Formula | C24H27NO6 |
| Molecular Weight | 425.47 g/mol |
| Compound Type | Boc/fluorenylmethyl-protected glutamic acid intermediate |
| Primary Research Use | Orthogonal glutamate protection, side-chain functionalization and cyclic-peptide route development |
Orthogonal Glutamate Protection
Boc-Glu-OFm combines Boc amino protection with a fluorenylmethyl ester in a glutamic-acid scaffold. The mixed protection pattern is useful when different functional groups must be exposed in separate operations rather than removed under one global condition.
Side-Chain and Cyclic-Peptide Route Design
Boc-Glu-OFm has been used in specialized peptide routes, including convergent and cyclic-peptide chemistry. Its practical advantage is selective functional-group access, so the exact regioisomer and planned deprotection sequence should be verified before attachment or ring-closing steps.
Selection and Procurement
Do not substitute another Boc-Glu ester solely because it shares the parent amino acid. Fluorenylmethyl, benzyl, tert-butyl and other ester groups respond to different cleavage conditions and can change the entire orthogonal protection strategy.
Additional chemistry is available in the specialty amino acid set. For synthesis planning beyond the building block, see specialty SPPS building blocks.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Why is Boc-Glu-OFm used in orthogonal synthesis?
Boc and fluorenylmethyl protection respond to different deprotection conditions, allowing glutamate functionality to be exposed in a controlled sequence.
Can another Boc-Glu ester be substituted directly?
Not automatically. Changing the ester can change deprotection selectivity and therefore the side-chain attachment or cyclization route.
What should be confirmed before use?
Confirm the exact regioisomer, CAS 133906-29-3 and which carboxyl group is protected in the supplied structure.