[Arg3]-Amyloid β-Protein (1-40) is a synthetic peptide variant of the amyloid β (Aβ) protein, featuring an arginine substitution at the third amino acid position (native Aβ(1-40) has alanine at this site). This modification alters the peptide’s charge and hydrophobicity, influencing its aggregation properties and interaction with cellular components. A key component of amyloid plaques in Alzheimer’s disease, Aβ(1-40) is associated with neurotoxicity and synaptic dysfunction. The [Arg3] variant is used in research to study how specific amino acid changes affect Aβ aggregation, fibril formation, and pathological signaling, aiding in the understanding of disease mechanisms and the development of therapeutic strategies targeting amyloidosis. By mimicking a naturally occurring or engineered mutation, this peptide serves as a valuable tool for investigating structure-function relationships in Aβ and evaluating potential inhibitors of amyloid aggregation for Alzheimer’s disease and related disorders.

Chemical Formula: C195H300N56O56S

Molecular Weight: 4356.97

Sequence: Asp-Ala-Arg-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Purity: From crude to 98%

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Research Use Only