β-Amyloid (1-42), human is a 42-amino acid peptide derived from the amyloid precursor protein (APP), crucial in the pathogenesis of Alzheimer’s disease. This hydrophobic peptide self-assembles into toxic oligomers and insoluble fibrils, forming the core of amyloid plaques in the brain, which are associated with neuronal dysfunction, synaptic loss, and neuroinflammation. The C-terminal region (residues 29–42) promotes aggregation and fibril formation, making β-Amyloid (1-42) more prone to pathological clustering compared to shorter Aβ variants. Widely used in research, it serves as a key tool to study amyloid aggregation mechanisms, evaluate anti-amyloid therapeutic candidates (e.g., monoclonal antibodies, aggregation inhibitors), and model neurotoxic pathways in Alzheimer’s disease. Understanding its structure-function relationship is critical for developing interventions targeting plaque formation, oligomer toxicity, and downstream neurodegenerative processes, supporting both basic neuroscience and translational drug discovery efforts.

Chemical Formula: C203H311N55O60S

Molecular Weight: 4514.10

Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Purity: From crude to 98%

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